Sildenafil Studied in Women With Antidepressant-Associated Sexual Dysfunction
After registering, you’ll receive timely updates and a notification as soon as your prescription is ready to be ordered through the DARE Health Hub in the coming months. Compounded medications like DARE to PLAY are typically not covered by insurance. However, many people are able to use FSA or HSA funds to pay for it.
Why is this medicine prescribed?
If you experience difficulty with sexual arousal, including a lack of physical response or reduced genital sensitivity during sexual activity, you may benefit from DARE to PLAY. A conversation with a licensed healthcare provider can help determine whether it is appropriate for you. DARE to PLAY contains the same active ingredient as Viagra®, but it’s formulated specifically for women and applied directly where it’s needed. Unlike an oral pill, DARE to PLAY is a topical cream designed to work locally rather than systemically. Apply the cream with your finger 10 to 15 minutes before sexual activity up to once per day.
Setting and Sample
Slowly squeeze out a length of cream about 2 ½ inches long for one 2-gram dose. Lying on your back, apply half the cream on and around the clitoris and the area around the vaginal opening, avoiding areas with hair. Apply the rest of the cream just inside the vagina, rubbing the cream with a curved finger on the front wall of the vagina. Once applied, do not wipe off any of the cream until after sexual activity. In the Phase 2b clinical study, women did not use lubricants because the study was specifically designed to evaluate the impact of DARE to PLAY on the genital arousal response. DARE to PLAY Sildenafil Cream will cost about $10 per sexual experience — less than your favorite coffee run, and way more satisfying. One, we’re not a telehealth company trying to make more money by pushing products on women that they don’t need. We develop real, differentiated solutions for women who want and need them. Two, we don’t want to assume that you will use DARE to PLAY a certain number of times per month.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Viagra Generic | 100mg | 180 + 8 Pills | 199.37€ 189.88€ | |
| Kamagra Soft Tabs | 100mg | 20 Pills | 79.79€ 75.99€ | |
| Viagra Generic | 25mg | 120 + 6 Pills | 125.56€ 119.58€ | |
| Kamagra Soft Tabs | 100mg | 12 Pills | 57.55€ 54.81€ | |
| Viagra Generic | 150mg | 20 Pills | 55.02€ 52.40€ | |
| Viagra Generic | 50mg | 20 Pills | 40.52€ 38.59€ | |
| Viagra Generic | 200mg | 10 Pills | 40.96€ 39.01€ | |
| Viagra Generic | 25mg | 360 + 10 Pills | 213.68€ 203.50€ | |
| Viagra Generic | 25mg | 20 Pills | 37.74€ 35.94€ | |
| Kamagra Soft Tabs | 100mg | 180 + 8 Pills | 425.45€ 405.19€ | |
| Kamagra Soft Tabs | 100mg | 84 + 4 Pills | 233.05€ 221.95€ | |
| Kamagra Oral Jelly | 100mg | 10 Sachets | 54.55€ 51.95€ | |
| Viagra Generic | 200mg | 180 + 10 Pills | 277.56€ 264.34€ | |
| Kamagra Polo | 100mg | 20 Pills | 83.56€ 79.58€ |
We will offer an option to auto-refill your prescription at a cadence that’s right for you, but we want to support and honor your choices and what feels right in your body, so whether one tube of DARE to PLAY lasts 10 days or one year–we think that’s perfect! Sign up to receive updates about DARE to PLAY and to be notified when it launches in your state. Diagnostic and Statistical Manual of Mental Disorders. The evolution of the female sexual disorder/dysfunction definitions, nomenclature, and classifications: a review of DSM, ICSM, ISSWSH, and ICD. doi: 10.1016/j.sxmr.2020.05.001 3 16% of women in the U.S. ages 21-60 are distressed from experiencing no or low sexual arousal, according to market research, and are actively seeking treatment. Ad Hoc Market Research: FSAD Prevalence Report (Oct 2015) conducted for SST LLC and based on US Census projections for 2016.
Are there any natural alternatives to Viagra for women?
In the Phase 2b clinical study, women were allowed to use DARE to PLAY during oral sex, and it was well tolerated with no significant safety concerns. Prior to the Phase 2b clinical study, DARE to PLAY was also tested in a preclinical study to assess its effects on the oral mucosa. These tests showed that daily exposure for 28 days did not cause irritation inside the mouth. The DARE to PLAY formulation does contain a proprietary combination of salts that support the absorption of sildenafil into the tissue. As a result, you may notice a mildly salty taste.
How much time does it take for Viagra to work for females?
DARE to PLAY can be used in both situations! In the Phase 2b clinical study, about 20% of sexual events were solo, and women reported that these experiences were often more satisfying than partnered events. Partnered events sometimes occurred under less-than-ideal conditions, like limited time or distractions, which can affect pleasure. DARE to PLAY is designed to complement, not replace, other approaches. It is a pharmacologic option focused on improving genital blood flow and physical responsiveness. 4 Thurman AR, Johnson I, Cornell KA, Hatheway J, Kim NN, Parish SJ, Dart C, Friend DR, Goldstein A. Safety of topical sildenafil cream, 3.6% in a randomized, placebo-controlled trial for the treatment of female sexual arousal disorder. 2024;21(9):793-799. doi:10.1093/jsxmed/qdae089 5 Goldstein S, Kukkonen T, Monsef A, Goldstein I. A double-blind, placebo-controlled, 2-way crossover study using thermography to assess the pharmacodynamics of sildenafil cream, 3.6% in healthy women.
How does it work?
Women often benefit most from a multimodal approach. DARE to PLAY is designed to improve physical arousal by increasing genital blood flow. Many women find that enhancing physical responsiveness can also help restore desire and confidence. In the Phase 2b clinical study, women with low desire due to diminished physical arousal sensations experienced improved desire following use of DARE to PLAY. If low desire is influenced by emotional or relationship factors, combining DARE to PLAY with other approaches—like counseling or therapy—may provide the best results.
Vyleesi (Bremalontide)
Yes, please see these instructions for how to get a prescription. Anyone who is licensed to write prescriptions can prescribe it—including your primary care provider (PCP), family medicine doctor, OB/GYN, nurse practitioner, physician assistant, or another qualified specialist. The DARE Health Hub (powered by Medvantx) is a nationwide pharmacy and telehealth service. Whether you use the DARE Health Hub telehealth offering to get your prescription or get a prescription from your provider, this is where you will order/fill your prescription. This service offers contact-free ordering and discreet delivery directly to your doorstep. doi:10.1016/j.jsxm.2019.11.194 6 sildenafil 100mg blue pill Johnson I, Thurman AR, Cornell KA, Hatheway J, Dart C, Brainard CP, Friend DR, Goldstein A.
- Awareness of sildenafil's potential side effects helps women make informed choices.
- Women should avoid using sildenafil with nitrates to prevent dangerous drops in blood pressure.
- Proper diagnosis of sexual dysfunction can guide appropriate treatment options.
- Scientific research continues to explore safer, women-specific sexual health drugs.
- Sildenafil’s long-term effects on women are not yet fully understood.
- Healthcare providers can help determine if sildenafil is appropriate for individual cases.
Preliminary efficacy of topical sildenafil cream for the treatment of female sexual arousal disorder: A randomized, placebo‑controlled, Phase 2b trial.
| Trend | Description | Potential Impact |
|---|---|---|
| Development of women-specific formulations | Customized doses and delivery methods | Improved safety and efficacy |
| Combination therapies | Sildenafil combined with other agents | Potentially enhanced outcomes |
| Non-oral delivery systems | Topicals, patches, or injectables | Increased convenience and quicker onset |
| Personalized medicine approaches | Genetic testing to optimize treatment | Higher success rates with fewer side effects |
| Increased clinical trials in women | More robust evidence for approval | Better guideline development |
Impact of age, race, and medication use on efficacy endpoints in a randomized controlled trial of topical sildenafil cream for the treatment of female sexual arousal disorder. Comparisons and correlations of 1‑month recall vs 24‑hour recall in patient‑reported outcomes of an exploratory, phase 2b, randomized, double‑blind, placebo‑controlled clinical trial of sildenafil cream, 3.6% for the treatment of female sexual arousal disorder. Symptoms and associated impact in pre‑ and postmenopausal women with sexual arousal disorder: a concept elicitation study. A New Topical Drug Delivery Platform: The Examples of Sildenafil and Ibuprofen.
- Some studies suggest sildenafil might help women with sexual arousal disorder.
- The drug's vasodilating effects can have cardiovascular implications in women.
- Women should be cautious of counterfeit or unapproved sildenafil products.
- Combining sildenafil with other ED drugs in women is not recommended without medical advice.
- Psychological support remains an important aspect of treating female sexual dysfunction.
- Ongoing clinical trials aim to establish the safety and efficacy of sildenafil for women.
11 American College of Obstetricians and Gynecologists. Preliminary efficacy of topical sildenafil cream for the treatment of female sexual arousal disorder [podcast episode]. The Green Room: A Podcast from Obstetrics & Gynecology. This product has not been reviewed by FDA for safety or efficacy.
Chemical synthesis
Here’s what you can expect depending on your preferred method of obtaining a prescription: Register for an account at the DARE Health Hub. After registering, you will be asked, “Have you seen a provider already?” Select “No” to initiate a telehealth consultation. You’ll then be asked to: Provide your address informationSign the telehealth sildenafil film tablet consent agreementFill out the telehealth questionnaireVerify your identification (by uploading a photo ID) Verify your identification (by uploading a photo ID) Within approximately 24 hours, your telehealth questionnaire responses will be reviewed by a licensed healthcare provider, and if medically appropriate, you will receive a prescription for DARE to PLAY. You can check the status of your prescription under “My Prescriptions” in the DARE Health Hub. You will be notified in the coming months, via email and text message, when ordering becomes available in your state.
Effects on sexual dysfunction
Ordering details will be added once available! Talk to your healthcare provider about DARE to PLAY. Bring the prescribing guide with you to your appointment. If your provider feels DARE to PLAY is medically appropriate for you, they will submit your prescription directly to the DARE Health Hub. You will then receive a phone call from the DARE Health Hub confirming receipt of your prescription and inviting you to register for an account. DARE to PLAY Sildenafil Cream is manufactured in a 503B outsourcing facility under pharmaceutical Good Manufacturing Practices (GMP). Viagra is an FDA-approved medication for erectile dysfunction (ED) in men.
- The legality of women using sildenafil varies by country and local regulations.
- Lifestyle modifications can complement medication for better sexual health outcomes.
- Women with diabetes may have different responses to sildenafil therapy.
- The stigma surrounding female sexual dysfunction can hinder treatment seeking.
- Advances in research are aimed at developing female-specific ED medications.
- Open discussions with physicians are essential for safe and effective treatments.
But it’s sometimes used off-label in women too. Viagra works by increasing blood flow to your genitals. For some women, this may help with sexual pleasure and satisfaction. There are two FDA-approved “female Viagra” medications too: Addyi and Vyleesi.
Statistical Analysis
However, there are no concerns about the compatibility of lubricants with the DARE to PLAY formulation. DARE to PLAY has been studied in both pre-and postmenopausal women to evaluate safety, tolerability, and how the drug is absorbed in the body (pharmacokinetics). In these studies, the cream was well tolerated. The Phase 2b clinical study enrolled healthy pre-and perimenopausal women aged 18 to 45 who had a diagnosis of Female Sexual Arousal Disorder (FSAD). Similar to FDA-approved products for Hypoactive Sexual Desire Disorder (HSDD), FSAD trials conducted for FDA review typically focus on either pre-or postmenopausal populations.
Hormone therapy
In the Phase 2b clinical study, approximately one-third of sildenafil 20 mg prescription the participants were taking an SSRI. An informal analysis compared women on SSRIs with those who were not and found that both groups showed positive trends in improved arousal sensations. Many vaginal products contain ingredients that can weaken condoms, increasing the risk of breakage. DARE to PLAY was tested using ASTM D7661-10, a standardized method that ensures a product is safe to use with condoms. Based on these tests, DARE to PLAY is compatible with all male condoms except those made of polyurethane. These are used to treat low libido in women, though it’s not clear how well they work.
- Sildenafil may help women with conditions like arousal disorder, but evidence varies.
- There is ongoing research into safe, effective female-specific doses of sildenafil.
- Side effects experienced by women can include dizziness, nausea, or visual disturbances.
- Consumption of alcohol while on sildenafil can increase side effect risks.
- Female sexual dysfunction can have psychological, hormonal, and physical causes.
- Sildenafil is not a cure-all; proper diagnosis is important for targeted treatment.
Many other medications, supplements, and lifestyle changes may also help with your sex life.
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