Do take it correctly
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of sildenafil in the elderly.
| Contraindication | Explanation | Notes |
|---|---|---|
| Use with Nitrates | Can cause severe hypotension | Avoid concurrent use |
| Severe Cardiovascular Disease | Increased risk of adverse events | Consult a doctor before use |
| Hypotension (<90/60 mmHg) | Risk of dangerously low blood pressure | Avoid use in hypotensive patients |
However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving sildenafil. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding.
Before Using
Tuttle, Lexington, Ky.; G. Wells, Birmingham, Ala.; C. White, Mobile, Ala.; J. Young, Laguna Hills, Calif.; and N. Zinner, Torrance, Calif.
Pulmonary hypertension
Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. Sex-ual behavior in the human male. Efficacy and safety of intracavernosal alprostadil in men with erectile dysfunction. Treatment of men with erectile dysfunction with transurethral alprostadil. Clinical Guidelines Panel on Erectile Dysfunction: summary report on the treatment of organic erectile dysfunction. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
| Parameter | Value | Description |
|---|---|---|
| Half-life | 4 hours | Time to reduce plasma concentration by half |
| Maximum plasma concentration | 0.8-1.5 hours | Peak effect timing |
| Absorption rate | Rapid, within 30-60 minutes | After oral administration |
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an 20mg sildenafil interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below.
- Do not take more than the prescribed dose of sildenafil tablets to avoid adverse effects.
- Limit fluid intake before and after taking sildenafil to prevent dehydration.
- Sildenafil tablets are not recommended for use in women or children.
The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
| Product | Dosage | Quantity + Bonus | Price | |
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| Kamagra Soft Tabs | 100mg | 120 + 6 Pills | 311.78€ 296.93€ | |
| Viagra Generic | 50mg | 60 + 4 Pills | 83.93€ 79.93€ | |
| Viagra Generic | 100mg | 270 + 10 Pills | 270.47€ 257.59€ | |
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| Viagra Generic | 50mg | 20 Pills | 40.52€ 38.59€ | |
| Kamagra Oral Jelly | 100mg | 10 Sachets | 54.55€ 51.95€ |
Using this medicine with any of the following medicines is not recommended.
What happens if I miss a dose?
Gleason, Tucson, Ariz.; F. Govier, Seattle; L. Hoffman, Gurnee, Ill.; J.M. Kaufman, Aurora, Colo.; I. Klimberg, Ocala, Fla.; V.
How should I store sildenafil?
Longo, New London, Conn.; T. Malloy, Philadelphia; A. McCullough, New York; J. McMurray, Huntsville, Ala.; D.F. ; J Susset, Providence, R.I.; J. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you.
- Sildenafil tablets may cause dizziness; avoid sudden movements after taking.
- Combining sildenafil with other medications for erectile dysfunction can increase risks.
- Always inform your healthcare provider about all medications you are using before starting sildenafil.
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur.
6.1 Clinical Trials Experience
Br J Clin Pract 1997;51:99-103 Any commercial reuse of NEJM Group content requires permission. From the Department of Urology, Boston University Medical Center, Boston (I.G. ); the Department of Urology, University of California, San Francisco (T.F.L. ); the Department of Urology, University of Southern California, Los Angeles, and the Male Clinic, Santa Monica, Calif. (H.P.-N.); the Department of Psychiatry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, N.J.
Jet lag research
); the Department of Urology, University of Virginia, Charlottesville (W.D.S. Select the format you want to export the citation of this publication. Multi-view semi-supervised adversarial attention network for drug repurposing, Computer Methods and Programs in Biomedicine, 282, (109406), (2026). Multi‐Target Mechanisms of Moroccan Aphrodisiac Plants: An Integrative Computational and Phytochemical Investigation, Food Science & Nutrition, 14, 5, (2026). Artificial intelligence in drug research and development: a review of methods and applications in drug repurposing, Briefings in Bioinformatics, 27, 3, (2026). Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases.
- Sildenafil is a PDE5 inhibitor specifically designed to treat erectile dysfunction.
- Use sildenafil tablets only as prescribed; do not share your medication.
- Contact your doctor if you notice an allergic reaction, such as swelling or rash.
If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.
Mechanism of action
Erectile dysfunction is a condition where the penis does not harden and expand when a man is sexually excited, or when he cannot keep an erection. When a man is sexually stimulated, his body's normal response is to increase blood flow to his penis to produce an erection. By controlling the enzyme, sildenafil helps to maintain an erection after the penis is stroked. Without physical action to the penis, such as that occurring during sexual intercourse, sildenafil will not work to cause an erection. Sildenafil is also used in both men and women to treat the symptoms of pulmonary arterial hypertension.
Patient resources
This is a type of high blood pressure that occurs between the heart and the lungs. When hypertension occurs in the lungs, the heart must work harder to pump enough blood through the lungs. Sildenafil works on the PDE5 enzyme in the lungs to relax the blood vessels. This will increase the supply of blood to the lungs and reduce the workload of the heart. This medicine is available only with your doctor's prescription. The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially: Abnormal penis, including a curved penis or birth defects of the penis—Chance of problems occurring may be increased and this medicine should be used with caution in these patients.
Chemical synthesis
Endocrine-metabolic crosstalk in erectile dysfunction: mechanistic insights and therapeutic implications, International Journal of Impotence Research, (2026). Therapeutic applications of phosphodiesterase inhibitors in male reproductive health: narrative review, Sexual Medicine Reviews, 14, 2, (2026). Oral suspension versus tablet sildenafil for erectile dysfunction: a prospective multicenter comparative tablet sildenafil 50 mg study on patient satisfaction, International Journal of Impotence Research, (2026). Low‐intensity shockwave therapy for erectile dysfunction: An abridged Cochrane review, BJU International, 137, 6, (949-957), (2026). Current state of the problem, Andrology and Genital Surgery, 25, 4, (33-40), (2026).
#7 Vardenafil(Levitra)
Emerging Trends and Research Focus in Erectile Dysfunction Treatment: A 1993–2023 Bibliometric Analysis, Andrologia, 2026, 1, (2026). Age > 65 years, hepatic impairment: 25 mg Severe renal impairment (CrCl < 30 ml/min): 25 mg Moderate hepatic impairment: initial 5 mg, max 10 mg Mild, moderate, severe renal impairment: No adjustment Mild or moderate hepatic impairment: max 10 mg once daily Moderate renal impairment: initial 5 mg once daily, max 10 mg every 48 hours Severe renal impairment (CrCl < 30 ml/min) on hemodialysis: max 5 mg Sildenafil is used to treat erectile dysfunction (also called sexual impotence). Sildenafil belongs to a group of medicines called phosphodiesterase 5 (PDE5) inhibitors. These medicines prevent an enzyme called phosphodiesterase type-5 from working too quickly. The penis is one of the areas where this enzyme works. Arrhythmia (irregular heartbeat, within the last 6 months) or Blood vessel problems (eg, aortic stenosis, idiopathic subaortic stenosis) or Heart attack (within the last 6 months) or Retinitis pigmentosa (an inherited eye disorder) or Stroke (within the last 6 months)—Should not be used in patients with these conditions.
5.3 Epistaxis
This product is available in the following dosage forms: In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Revatio Injection
Appropriate studies have not been performed on the relationship of age to the effects of sildenafil in children younger than 1 year of age. Safety and efficacy have not been established. Sildenafil should never be used in children for erectile dysfunction. In general, sildenafil should not be used for pulmonary arterial hypertension in children, especially for chronic use. Use of sildenafil oral film is not indicated for use in the pediatric population. Crowded disc or low cup to disc ratio in the eye (an eye disorder) or Hyperlipidemia (high fats in the blood) or Non-arteritic anterior ischemic optic neuropathy or NAION (serious eye condition), history of or Retinitis pigmentosa (an inherited eye disorder) or Smoking—May increase the chance for a serious side effect in the eye called NAION. Stomach ulcer, or history of or—Chance of problems occurring may be increased. It is not known if the medicine is safe for use in these patients.
More about sildenafil
Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. N Engl sildenafil pfizer 100g J Med 1992;326:90-94 Andersson, K-E, Wagner, G. Physiology of penile erection. The role of nitric oxide in the physiology of erection. Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction.
Viagra Tablets
Sildenafil, a novel effective oral therapy for male erectile dysfunction. Br J Urol 1996;78:257-261 Rosen, RC, Riley, A, Wagner, G, Osterloh, IH, Kirkpatrick, J, Mishra, A. The International Index of Erectile Function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Riley, AJ, Athanasiadis, L. Impotence and its non-surgical management. The effects may be increased because of slower removal of the medicine from the body.
- Sildenafil tablets may interact with medications like alpha-blockers and certain antibiotics.
- Overdose symptoms include severe hypotension, headache, and visual disturbances.
- Always keep sildenafil tablets out of reach of children and pets.
Sickle-cell anemia (blood disorder)—Sildenafil should be used with caution in these patients as problems with prolonged erection of the penis may occur. Pulmonary arterial hypertension (high blood pressure in the lungs) or Pulmonary veno-occlusive disease or PVOD (a type of lung disease)—Use with caution.
| Side Effect | Severity | Frequency | Recommendations |
|---|---|---|---|
| Headache | Mild | Common | Take analgesics |
| Flushing | Mild | Common | Cool environment |
| Nasal Congestion | Mild | Sometimes | Use decongestants |
| Dizziness | Mild | Less common | Avoid sudden movements |
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